The Differential Clinical Impacts of Cachexia and Sarcopenia on the Prognosis of Advanced Pancreatic Cancer

Ya Chin Hou, Chien Yu Chen, Chien Jui Huang, Chih Jung Wang, Ying Jui Chao, Nai Jung Chiang, Hao Chen Wang, Hui Ling Tung, Hsiao Chun Liu, Yan Shen Shan

研究成果: Article同行評審

摘要

Pancreatic cancer (PC) has the highest frequency of developing cancer cachexia (CC)– sarcopenia (SC) syndrome, which negatively influences patients’ outcome, quality of life, and toler-ance/response to treatments. However, the clinical impacts of CC, SC, and their associated factors on outcomes for advanced PC has yet to be fully investigated. A total of 232 patients were enrolled in this study for the retrospective review of their clinical information and the measurement of skeletal muscle areas at the third lumber vertebra by computed tomography scan to identify CC or SC. The association and concurrent occurrence of clinicopathological features in each patient, prevalence rates, and prognosis with the CC or SC were calculated. CC and SC were observed in 83.6% (n = 194) and 49.1% (n = 114) of PC patients, respectively. Low hemoglobin levels more often occurred in CC patients than in non-CC patients (p = 0.014). Older age (p = 0.000), female gender (p = 0.024), low body mass index (BMI) values (p = 0.004), low hemoglobin levels (p = 0.036), and low albumin levels (p = 0.001) were more often found in SC patients than in non-SC patients. Univariate and multivariate analyses showed that CC was an independent poor prognostic factor of overall survival (OS) and progression-free survival for all patients, the chemotherapy (C/T) subgroup, and the high BMI subgroup. Meanwhile, SC was an independent predictor of poor OS for the subgroups of C/T or high BMI but not for all patients. These findings reveal the clinical differences for CC and SC and provide useful information for predicting the prognosis of advanced PC patients and conducting personalized medicine.

原文English
文章編號3137
期刊Cancers
14
發行號13
DOIs
出版狀態Published - 2022 7月 1

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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