The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat

Yu Wen Chen, Chin Chen Chu, Yu Chung Chen, Jhi Joung Wang, Ching-Hsia Hung

研究成果: Article

10 引文 (Scopus)

摘要

The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED50) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (P<0.01 for each comparison). On an equipotent basis (ED25, ED50, and ED75), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (P<0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.

原文English
頁(從 - 到)76-80
頁數5
期刊Neuroscience Letters
482
發行號1
DOIs
出版狀態Published - 2010 九月 1

指紋

Diltiazem
Spinal Anesthesia
Mepivacaine
Verapamil
Anesthetics
Local Anesthetics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

引用此文

Chen, Yu Wen ; Chu, Chin Chen ; Chen, Yu Chung ; Wang, Jhi Joung ; Hung, Ching-Hsia. / The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat. 於: Neuroscience Letters. 2010 ; 卷 482, 編號 1. 頁 76-80.
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The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat. / Chen, Yu Wen; Chu, Chin Chen; Chen, Yu Chung; Wang, Jhi Joung; Hung, Ching-Hsia.

於: Neuroscience Letters, 卷 482, 編號 1, 01.09.2010, p. 76-80.

研究成果: Article

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