The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice

Dur Zong Hsu, Se Ping Chien, Ke Ting Chen, Ming Yie Liu

研究成果: Article同行評審

45 引文 斯高帕斯(Scopus)

摘要

This study investigated the effect of sesamol (3,4-methylenedioxyphenol) on systemic oxidative stress and hepatic function in acutely iron-intoxicated mice. Sesamol reduced the levels of lipid peroxidation, hydroxyl radical, iron production and superoxide anion generation, and xanthine oxidase activity in iron-intoxicated mice. In addition, sesamol decreased the serum levels of aspartate aminotransferase and alanine aminotransferase, and ameliorated iron-intoxication-induced histological changes in the liver. In summary, sesamol might attenuate systemic oxidative stress by reducing xanthine oxidase and improving hepatic function in iron-intoxicated mice.

原文English
頁(從 - 到)596-601
頁數6
期刊Shock
28
發行號5
DOIs
出版狀態Published - 2007 十一月

All Science Journal Classification (ASJC) codes

  • 急診醫學
  • 重症監護和重症監護醫學

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