The efficiency of transdermal α-Arbutin delivery after albumin microbubbles treatment with ultrasound in mice

Ai Ho Liao, Wan Chun Ma, Ho Chiao Chuang, Chih Kuang Yeh, Chih Chung Huang

研究成果: Conference contribution

摘要

The application of transdermal delivery to a wider range of drugs is limited due to the significant barrier to penetration across the skin which is associated with the stratum corneum layer of the epidermis. In previous study in the literature, the feasibility and effects of the ultrasound (US) contrast agent, microbubbles (MBs) as the penetration enhancers for transdermal delivery in vivo were firstly demonstrated. In this study, the penetration depth, concentration, and efficiency of transdermal α-Arbutin delivery after MBs treatment with US in mice were demonstrated for 4 weeks. The penetration of α-arbutin on skin was enhanced by using ultrasound energy and MBs either for in vitro or for in vivo experiments. Experiment parameters were randomly divided into four groups (n=5 animals per group): (1) only penetrating α-Arbutin (C); (2) US combines with penetrating α-arbutin (U) (3) US combines with MBs contrast agent and penetrating α-arbutin (UB); (4) US combines with diluted MBs and penetrating α-arbutin (UBD). According to the results, the penetration depth of agarose phantom and pigskin of UBD group increase 47% and 84%, respectively. The in vitro skin permeation of 2% α-arbutin, UBD group was 83% greater than control group after 3 hour of permeation study. For in vivo study, the whitening effect (luminosity index) of mice skin in UBD group significantly increase 25% in one week, 34% in two weeks and tends towards stability in three weeks (37%) in C57BL/6J mice over a 4-week experimental period. Our results investigated that the treatments of ultrasound and MBs can increase skin permeability, enhance α-arbutin delivery to inhibit melanogenesis and not damage the skin in mice.

原文English
主出版物標題9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
發行者Institute of Electrical and Electronics Engineers Inc.
頁面163-167
頁數5
ISBN(電子)9781479947270
DOIs
出版狀態Published - 2014 九月 23
事件9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 - Waikiki Beach, United States
持續時間: 2014 四月 132014 四月 16

出版系列

名字9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

Other

Other9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
國家/地區United States
城市Waikiki Beach
期間14-04-1314-04-16

All Science Journal Classification (ASJC) codes

  • 控制與系統工程
  • 電氣與電子工程

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