The evolutionary rate of a protein is influenced by features of the interacting partners

Takashi Makino, Takashi Gojobori

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.

原文English
頁(從 - 到)784-789
頁數6
期刊Molecular Biology and Evolution
23
發行號4
DOIs
出版狀態Published - 2006 4月

All Science Journal Classification (ASJC) codes

  • 生態學、進化論、行為學與系統學
  • 分子生物學
  • 遺傳學

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