摘要
Rates of protein evolution are thought to be influenced by features of protein-protein interaction (PPI). However, the most important features of interaction for determining the evolutionary rate are poorly understood. Here, we consider four categories for PPIs in Saccharomyces cerevisiae. Properties we consider are the extent to which proteins interact with proteins of the same function or different function (DF) and the extent to which these interactions involve connections in the dense part or sparse part (SP) of a PPI network. Our findings are that proteins with DF-SP interactions evolve at the slowest rate of all the proteins examined.
原文 | English |
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頁(從 - 到) | 784-789 |
頁數 | 6 |
期刊 | Molecular Biology and Evolution |
卷 | 23 |
發行號 | 4 |
DOIs | |
出版狀態 | Published - 2006 4月 |
All Science Journal Classification (ASJC) codes
- 生態學、進化論、行為學與系統學
- 分子生物學
- 遺傳學