The expression of p53 and bcl-2 in superficial bladder transitional cell carcinoma and its role in the outcome of postoperative intravesical chemotherapy

Tzong Shin Tzai, Nan-Haw Chow, Johnny Shinn Nan Lin, Wen-Horng Yang, Yat-Ching Tong

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

Background: We evaluated whether p53 and bcl-2 expression has any predictive value on the outcome of postoperative adjuvant intravesical chemotherapy for superficial bladder transitional cell carcinoma (TCC). Materials and Methods: Immunostaining for p53 and bcl-2 was performed on paraffin-embedded tumor tissues obtained from 100 patients with superficial bladder TCC. 56 had solitary and 44 had multiple tumors; 36 were grade I, 53 grade II and 11 grade III; 50 were stage pTa and 50 stage pT1. They all received transurethral resection (TUR) and weekly intravesical instillation chemotherapy with either Thiotepa (70 patients) or Epirubicin (30 patients) for consecutive 8 doses postoperatively. Results: Overall, 7 (7%) tumors were p53+ and 12 (12%) tumors were bcl-2+. Of these, only one tumor was combined p53+ and bcl-2+. The status of tumor p53 and bcl-2 positivity was found to be not significantly correlated with either tumor grade or stage. After adjuvant intravesical chemotherapy, tumor recurrence is significantly correlated with tumor multifocality (p = 0.0002) but not with tumor grade and stage. Compared with p53- or bcl-2- tumors, patients with p53+ or bcl-2+ tumors do not show a higher tumor recurrence rate. The number of recurrence-free patients was also not significantly different in patients eventually developed disease progression, and none stained positively for either p53 or bcl-2. Conclusions: We conclude that in superficial bladder TCC the status of tumor p53 and bcl-2 expression is not correlated with stage of tumor p53 and bcl-2 expression is not correlated with stage and grade. Their expression, either alone or combined, has no predictive role on the outcome of post-TUR intravesical chemotherapy on tumor recurrence.

原文English
頁(從 - 到)4717-4721
頁數5
期刊Anticancer research
18
發行號6 B
出版狀態Published - 1998 十二月 1

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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