The fate of Phellamurin in rats

Hung Yi Chen, Tian-Shung Wu, Jih Pyang Wang, Sheng Chu Kuo, Pei Dawn Lee Chao

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). The metabolism and disposition of phellamurin were investigated in rats. Doses of 100 mg/kg and 200 mg/kg were orally administered to rats and blood samples were withdrawn by cardiopuncture at specific times. Serum concentrations of the aglycone were determined by an HPLC method prior to and after hydrolysis with β-glucuronidase. The mobile phase was acetonitrile: H2O (containing 1% acetic acid, 38:62, v/v). The pharmacokinetic parameters were calculated by using the noncompartment model of WINNONLIN. Our results indicate that the parent compound was not absorbed. Hydrolysis to phellamuretin resulted in rapid absorption and subsequent conversion to glucuronides. The pharmacokinetic parameters after two doses were not significantly different. Phellamuretin and phellamuretin glucuronides accounted for 20 % and 80 % of the metabolites of phellamurin, respectively, for both doses.

原文English
頁(從 - 到)37-44
頁數8
期刊Chinese Pharmaceutical Journal
53
發行號1
出版狀態Published - 2001 二月 1

All Science Journal Classification (ASJC) codes

  • 藥理
  • 藥學科學

指紋

深入研究「The fate of Phellamurin in rats」主題。共同形成了獨特的指紋。

引用此