The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins

Weiping Peng, Gail Henderson, Guey Chuen Perng, Anthony B. Nesburn, Steven L. Wechsler, Clinton Jones

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

原文English
頁(從 - 到)10714-10718
頁數5
期刊Journal of Virology
77
發行號19
DOIs
出版狀態Published - 2003 十月

All Science Journal Classification (ASJC) codes

  • 微生物學
  • 免疫學
  • 昆蟲科學
  • 病毒學

指紋

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