The Immunogenetics of Photodermatoses

Chaw Ning Lee, Tzu Ying Chen, Tak Wah Wong

研究成果: Chapter

摘要

Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Idiopathic photodermatoses, a spectrum of diseases with abnormal responses to ultraviolet radiation (UVR), include polymorphous light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, and solar urticaria. Young people are more susceptible to most idiopathic photodermatoses except for chronic actinic dermatitis. Interestingly, idiopathic photodermatoses exhibit different characteristics between Caucasians and Asians. For example, the average age of Asian actinic prurigo patients is older than that of Caucasians in which genetic backgrounds or Fitzpatrick skin type might play a role. Drug-induced photodermatoses can be classified into phototoxic and photoallergic drug reactions. Certain drug-induced photodermatoses may mimic other dermatoses. For instance, drug-induced lupus erythematosus (LE) should be considered if an old man is diagnosed with LE but had a poor response to standard treatments.

原文English
主出版物標題Advances in Experimental Medicine and Biology
發行者Springer
頁面369-381
頁數13
DOIs
出版狀態Published - 2022

出版系列

名字Advances in Experimental Medicine and Biology
1367
ISSN(列印)0065-2598
ISSN(電子)2214-8019

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)

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