The impact of the surfactant type on physicochemical properties, encapsulation, and in vitro biocompatibility of coconut oil nanoemulsions

I. Ting Hsieh, Jo Shu Chang, Tzung Han Chou

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background: This study investigated the effects of the three types of surfactants including polyethylene glycol 100-stearate (S-PEG100), hydrogenated soybean lecithin (HL), and dimethyldiocatadecylammonium (DODAB) on the physicochemical characteristics, encapsulation, and in vitro biocompatibility of coconut oil (CO) nanoemulsions (NEs). Methods: Size distribution, zeta-potential, structure, and storage stability of the CO NEs were comprehensively studied. The intra-particle and rheological properties of NEs were assessed by using differential scanning calorimetry, fluorescence polarization analysis, and viscosity measurement. The in vitro biocompatibility and the encapsulation efficiency of CO NEs emulsified with S-PEG100, HL, and DODAB were also evaluated. Significant Findings: The size order was S-PEG100-<HL-<DODAB- CO NEs. The main phase-transition enthalpy, main phase-transition temperature, and intra-particle fluidity of CO NEs with HL and DODAB increased with increasing the surfactant/oil ratio, whereas they decreased for NEs with S-PEG100. Moreover, CO NEs with S-PEG100 and HL exhibited Newtonian fluid behavior, while NEs with DODAB behaved like pseudoplastic fluid. Furthermore, the cytotoxicity of NEs with DODAB was higher than those with S-PEG100 and HL. The encapsulation efficiency of NEs with DODAB was higher than those with S-PEG100 and HL.

原文English
文章編號104217
期刊Journal of the Taiwan Institute of Chemical Engineers
137
DOIs
出版狀態Published - 2022 8月

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 化學工程 (全部)

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