TY - JOUR
T1 - The impact of the surfactant type on physicochemical properties, encapsulation, and in vitro biocompatibility of coconut oil nanoemulsions
AU - Hsieh, I. Ting
AU - Chang, Jo Shu
AU - Chou, Tzung Han
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology in Taiwan through Grants MOST 109–2221-E-224–032 and MOST 110–2221-E-224–003, 110–3116-F-006 −003, 110–2221-E-029 −004 -MY3, 110–2621-M-029 −001, and 109–2622-E-110 −01
Publisher Copyright:
© 2022 Taiwan Institute of Chemical Engineers
PY - 2022/8
Y1 - 2022/8
N2 - Background: This study investigated the effects of the three types of surfactants including polyethylene glycol 100-stearate (S-PEG100), hydrogenated soybean lecithin (HL), and dimethyldiocatadecylammonium (DODAB) on the physicochemical characteristics, encapsulation, and in vitro biocompatibility of coconut oil (CO) nanoemulsions (NEs). Methods: Size distribution, zeta-potential, structure, and storage stability of the CO NEs were comprehensively studied. The intra-particle and rheological properties of NEs were assessed by using differential scanning calorimetry, fluorescence polarization analysis, and viscosity measurement. The in vitro biocompatibility and the encapsulation efficiency of CO NEs emulsified with S-PEG100, HL, and DODAB were also evaluated. Significant Findings: The size order was S-PEG100-<HL-<DODAB- CO NEs. The main phase-transition enthalpy, main phase-transition temperature, and intra-particle fluidity of CO NEs with HL and DODAB increased with increasing the surfactant/oil ratio, whereas they decreased for NEs with S-PEG100. Moreover, CO NEs with S-PEG100 and HL exhibited Newtonian fluid behavior, while NEs with DODAB behaved like pseudoplastic fluid. Furthermore, the cytotoxicity of NEs with DODAB was higher than those with S-PEG100 and HL. The encapsulation efficiency of NEs with DODAB was higher than those with S-PEG100 and HL.
AB - Background: This study investigated the effects of the three types of surfactants including polyethylene glycol 100-stearate (S-PEG100), hydrogenated soybean lecithin (HL), and dimethyldiocatadecylammonium (DODAB) on the physicochemical characteristics, encapsulation, and in vitro biocompatibility of coconut oil (CO) nanoemulsions (NEs). Methods: Size distribution, zeta-potential, structure, and storage stability of the CO NEs were comprehensively studied. The intra-particle and rheological properties of NEs were assessed by using differential scanning calorimetry, fluorescence polarization analysis, and viscosity measurement. The in vitro biocompatibility and the encapsulation efficiency of CO NEs emulsified with S-PEG100, HL, and DODAB were also evaluated. Significant Findings: The size order was S-PEG100-<HL-<DODAB- CO NEs. The main phase-transition enthalpy, main phase-transition temperature, and intra-particle fluidity of CO NEs with HL and DODAB increased with increasing the surfactant/oil ratio, whereas they decreased for NEs with S-PEG100. Moreover, CO NEs with S-PEG100 and HL exhibited Newtonian fluid behavior, while NEs with DODAB behaved like pseudoplastic fluid. Furthermore, the cytotoxicity of NEs with DODAB was higher than those with S-PEG100 and HL. The encapsulation efficiency of NEs with DODAB was higher than those with S-PEG100 and HL.
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U2 - 10.1016/j.jtice.2022.104217
DO - 10.1016/j.jtice.2022.104217
M3 - Article
AN - SCOPUS:85123380271
VL - 137
JO - Journal of the Taiwan Institute of Chemical Engineers
JF - Journal of the Taiwan Institute of Chemical Engineers
SN - 1876-1070
M1 - 104217
ER -