The interaction of oxytocin and social support, loneliness, and cortisol level in major depression

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13 引文 斯高帕斯(Scopus)


Objective: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness and hypothalamic-pituitary-adrenal (HPA)-axis activity in drug-naïve patients with major depressive disorder (MDD). Methods: Twenty-six patients with MDD (male:female = 3:23; mean age, 45.54 ± 12.97 years) were recruited. The 17-item Hamilton Depression Rating Scale, UCLA Loneliness Scale and self-reported Measurement of Support Function Questionnaire were administered. Serum oxytocin and cortisol levels were assessed using a commercial immunoassay kits. Results: In MDD patients, a negative association was found between degrees of social support and loneliness (β =-0.39, p = 0.04). The interaction between social support and serum oxytocin level was negatively associated with loneliness (β =-0.50, p = 0.017) and serum cortisol level (β =-0.55, p = 0.020) after adjusting for age. Follow-up analyses showed that the association between higher social support and lower loneliness was observed only in the higher-oxytocin group (r =-0.75, p = 0.003) but not in the lower group (r =-0.19, p = 0.53). The significance remained after further adjusting for sex and depression severity. Conclusion: Low oxytocin level is a vulnerability factor for the buffering effect of social support for loneliness and aberrant HPA-axis activity in MDD patients.

頁(從 - 到)487-494
期刊Clinical Psychopharmacology and Neuroscience
出版狀態Published - 2019

All Science Journal Classification (ASJC) codes

  • 精神病學和心理健康
  • 行為神經科學
  • 藥學(醫學)


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