The interplay between alcohol consumption, oral hygiene, ALDH2and ADH1B in the risk of head and neck cancer

Sen Tien Tsai, Tung Yiu Wong, Chun Yen Ou, Sheen Yie Fang, Ken Chung Chen, Jenn Ren Hsiao, Cheng Chih Huang, Wei Ting Lee, Hung I. Lo, Jehn Shyun Huang, Jiunn Liang Wu, Chia Jui Yen, Wei Ting Hsueh, Yuan Hua Wu, Ming Wei Yang, Forn Chia Lin, Jang Yang Chang, Kwang Yu Chang, Shang Yin Wu, Hsiao Chen LiaoChen Lin Lin, Yi Hui Wang, Ya Ling Weng, Han Chien Yang, Jeffrey S. Chang

研究成果: Article

32 引文 (Scopus)

摘要

Alcohol consumption is an established risk factor for head and neck cancer (HNC). The major carcinogen from alcohol is acetaldehyde, which may be produced by humans or by oral microorganisms through the metabolism of ethanol. To account for the different sources of acetaldehyde production, the current study examined the interplay between alcohol consumption, oral hygiene (as a proxy measure for the growth of oral microorganisms), and alcohol-metabolizing genes ( ADH1B and ALDH2) in the risk of HNC. We found that both the fast (∗2/∗2) and the slow (∗1/∗1 +∗1/∗2) ADH1B genotypes increased the risk of HNC due to alcohol consumption, and this association differed according to the slow/non-functional ALDH2 genotypes (∗1/∗2 +∗2/∗2) or poor oral hygiene. In persons with the fast ADH1B genotype, the HNC risk associated with alcohol drinking was increased for those with the slow/non-functional ALDH2 genotypes. For those with the slow ADH1B genotypes, oral hygiene appeared to play an important role; the highest magnitude of an increased HNC risk in alcohol drinkers occurred among those with the worst oral hygiene. This is the first study to show that the association between alcohol drinking and HNC risk may be modified by the interplay between genetic polymorphisms of ADH1B and ALDH2 and oral hygiene. Although it is important to promote abstinence from or reduction of alcohol drinking to decrease the occurrence of HNC, improving oral hygiene practices may provide additional benefit.

原文English
頁(從 - 到)2424-2436
頁數13
期刊International Journal of Cancer
135
發行號10
DOIs
出版狀態Published - 2014 十一月 15

指紋

Oral Hygiene
Head and Neck Neoplasms
Alcohol Drinking
Genotype
Acetaldehyde
Alcohols
Mouth Neoplasms
Proxy
Genetic Polymorphisms
Carcinogens
Ethanol
Growth
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

@article{93e27097beeb4ac4aab01f06ff759919,
title = "The interplay between alcohol consumption, oral hygiene, ALDH2and ADH1B in the risk of head and neck cancer",
abstract = "Alcohol consumption is an established risk factor for head and neck cancer (HNC). The major carcinogen from alcohol is acetaldehyde, which may be produced by humans or by oral microorganisms through the metabolism of ethanol. To account for the different sources of acetaldehyde production, the current study examined the interplay between alcohol consumption, oral hygiene (as a proxy measure for the growth of oral microorganisms), and alcohol-metabolizing genes ( ADH1B and ALDH2) in the risk of HNC. We found that both the fast (∗2/∗2) and the slow (∗1/∗1 +∗1/∗2) ADH1B genotypes increased the risk of HNC due to alcohol consumption, and this association differed according to the slow/non-functional ALDH2 genotypes (∗1/∗2 +∗2/∗2) or poor oral hygiene. In persons with the fast ADH1B genotype, the HNC risk associated with alcohol drinking was increased for those with the slow/non-functional ALDH2 genotypes. For those with the slow ADH1B genotypes, oral hygiene appeared to play an important role; the highest magnitude of an increased HNC risk in alcohol drinkers occurred among those with the worst oral hygiene. This is the first study to show that the association between alcohol drinking and HNC risk may be modified by the interplay between genetic polymorphisms of ADH1B and ALDH2 and oral hygiene. Although it is important to promote abstinence from or reduction of alcohol drinking to decrease the occurrence of HNC, improving oral hygiene practices may provide additional benefit.",
author = "Tsai, {Sen Tien} and Wong, {Tung Yiu} and Ou, {Chun Yen} and Fang, {Sheen Yie} and Chen, {Ken Chung} and Hsiao, {Jenn Ren} and Huang, {Cheng Chih} and Lee, {Wei Ting} and Lo, {Hung I.} and Huang, {Jehn Shyun} and Wu, {Jiunn Liang} and Yen, {Chia Jui} and Hsueh, {Wei Ting} and Wu, {Yuan Hua} and Yang, {Ming Wei} and Lin, {Forn Chia} and Chang, {Jang Yang} and Chang, {Kwang Yu} and Wu, {Shang Yin} and Liao, {Hsiao Chen} and Lin, {Chen Lin} and Wang, {Yi Hui} and Weng, {Ya Ling} and Yang, {Han Chien} and Chang, {Jeffrey S.}",
year = "2014",
month = "11",
day = "15",
doi = "10.1002/ijc.28885",
language = "English",
volume = "135",
pages = "2424--2436",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "10",

}

TY - JOUR

T1 - The interplay between alcohol consumption, oral hygiene, ALDH2and ADH1B in the risk of head and neck cancer

AU - Tsai, Sen Tien

AU - Wong, Tung Yiu

AU - Ou, Chun Yen

AU - Fang, Sheen Yie

AU - Chen, Ken Chung

AU - Hsiao, Jenn Ren

AU - Huang, Cheng Chih

AU - Lee, Wei Ting

AU - Lo, Hung I.

AU - Huang, Jehn Shyun

AU - Wu, Jiunn Liang

AU - Yen, Chia Jui

AU - Hsueh, Wei Ting

AU - Wu, Yuan Hua

AU - Yang, Ming Wei

AU - Lin, Forn Chia

AU - Chang, Jang Yang

AU - Chang, Kwang Yu

AU - Wu, Shang Yin

AU - Liao, Hsiao Chen

AU - Lin, Chen Lin

AU - Wang, Yi Hui

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chang, Jeffrey S.

PY - 2014/11/15

Y1 - 2014/11/15

N2 - Alcohol consumption is an established risk factor for head and neck cancer (HNC). The major carcinogen from alcohol is acetaldehyde, which may be produced by humans or by oral microorganisms through the metabolism of ethanol. To account for the different sources of acetaldehyde production, the current study examined the interplay between alcohol consumption, oral hygiene (as a proxy measure for the growth of oral microorganisms), and alcohol-metabolizing genes ( ADH1B and ALDH2) in the risk of HNC. We found that both the fast (∗2/∗2) and the slow (∗1/∗1 +∗1/∗2) ADH1B genotypes increased the risk of HNC due to alcohol consumption, and this association differed according to the slow/non-functional ALDH2 genotypes (∗1/∗2 +∗2/∗2) or poor oral hygiene. In persons with the fast ADH1B genotype, the HNC risk associated with alcohol drinking was increased for those with the slow/non-functional ALDH2 genotypes. For those with the slow ADH1B genotypes, oral hygiene appeared to play an important role; the highest magnitude of an increased HNC risk in alcohol drinkers occurred among those with the worst oral hygiene. This is the first study to show that the association between alcohol drinking and HNC risk may be modified by the interplay between genetic polymorphisms of ADH1B and ALDH2 and oral hygiene. Although it is important to promote abstinence from or reduction of alcohol drinking to decrease the occurrence of HNC, improving oral hygiene practices may provide additional benefit.

AB - Alcohol consumption is an established risk factor for head and neck cancer (HNC). The major carcinogen from alcohol is acetaldehyde, which may be produced by humans or by oral microorganisms through the metabolism of ethanol. To account for the different sources of acetaldehyde production, the current study examined the interplay between alcohol consumption, oral hygiene (as a proxy measure for the growth of oral microorganisms), and alcohol-metabolizing genes ( ADH1B and ALDH2) in the risk of HNC. We found that both the fast (∗2/∗2) and the slow (∗1/∗1 +∗1/∗2) ADH1B genotypes increased the risk of HNC due to alcohol consumption, and this association differed according to the slow/non-functional ALDH2 genotypes (∗1/∗2 +∗2/∗2) or poor oral hygiene. In persons with the fast ADH1B genotype, the HNC risk associated with alcohol drinking was increased for those with the slow/non-functional ALDH2 genotypes. For those with the slow ADH1B genotypes, oral hygiene appeared to play an important role; the highest magnitude of an increased HNC risk in alcohol drinkers occurred among those with the worst oral hygiene. This is the first study to show that the association between alcohol drinking and HNC risk may be modified by the interplay between genetic polymorphisms of ADH1B and ALDH2 and oral hygiene. Although it is important to promote abstinence from or reduction of alcohol drinking to decrease the occurrence of HNC, improving oral hygiene practices may provide additional benefit.

UR - http://www.scopus.com/inward/record.url?scp=84909956817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84909956817&partnerID=8YFLogxK

U2 - 10.1002/ijc.28885

DO - 10.1002/ijc.28885

M3 - Article

C2 - 24719202

AN - SCOPUS:84909956817

VL - 135

SP - 2424

EP - 2436

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 10

ER -