The involvement of metabotropic glutamate receptors in long-term depression of N-methyl-d-aspartate receptor-mediated synaptic potential in the rat hippocampus

Pei Lu Yi, Fang Chia Chang, Jing Jane Tsai, Chen Road Hung, Po Wu Gean

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

The frequency-dependent long-term modifications of pharmacologically isolated N-methyl-d-aspartate (NMDA) receptor-mediated excitatory postsynaptic potential (EPSPNMDA) was studied. Intracellular recordings were obtained from CA1 cells of rat hippocampal slices and in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (10 μM) and bicuculline (20 μM) which block non-NMDA and GABAA receptors, respectively. Low-frequency stimulation at 5 Hz resulted in a long-term depression (LTD) of EPSPNMDA in 12 of 17 cells. However, when the stimulus frequency was increased to 30 Hz, a long-term potentiation (LTP) of EPSPNMDA was observed in 7 out of 9 cells. The LTD was not affected by pretreating the slices with okadaic acid (0.5-1 μM) suggesting that activation of endogenous protein phosphatase is not responsible for this process. In the presence of l-2-amino-3-phosphonopropionic acid (50 μM) or (RS)-α-methyl-4-carboxyphenylglycine (200 μM), 5 Hz tetanization resulted in LTP instead of LTD. These results suggest that activation of metabotropic glutamate receptor (mGluR) is necessary for the induction of EPSPNMDA LTD and blockade of mGluR unmasks a LTP.

原文English
頁(從 - 到)207-210
頁數4
期刊Neuroscience Letters
185
發行號3
DOIs
出版狀態Published - 1995 二月 13

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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