The migration of cancer and normal cells in response to the surface topography and rigidity

Wen Chi Chen; Chin Ho Hsieh; Chia Hui Li; Yu Chieh Tseng; Kuo Ming Wang; Ming Long Yeh

doi:10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity

Wen Chi Chen, Chin Ho Hsieh, Chia Hui Li, Yu Chieh Tseng, Kuo Ming Wang, Ming Long Yeh

研究成果: Conference contribution

1 引文斯高帕斯（Scopus）

摘要

Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

原文	English
主出版物標題	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
頁面	483-486
頁數	4
DOIs	https://doi.org/10.1109/NEMS.2011.6017398
出版狀態	Published - 2011
事件	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan 持續時間: 2011 2月 20 → 2011 2月 23

出版系列

名字	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Other

Other	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
國家/地區	Taiwan
城市	Kaohsiung
期間	11-02-20 → 11-02-23

All Science Journal Classification (ASJC) codes

原子與分子物理與光學

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1109/NEMS.2011.6017398

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引用此

Chen, W. C., Hsieh, C. H., Li, C. H., Tseng, Y. C., Wang, K. M., & Yeh, M. L. (2011). The migration of cancer and normal cells in response to the surface topography and rigidity. 於 NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (頁 483-486). 文章 6017398 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). https://doi.org/10.1109/NEMS.2011.6017398

@inproceedings{e655c3cb225c4258aafbc1698a8c4385,

title = "The migration of cancer and normal cells in response to the surface topography and rigidity",

abstract = "Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.",

author = "Chen, {Wen Chi} and Hsieh, {Chin Ho} and Li, {Chia Hui} and Tseng, {Yu Chieh} and Wang, {Kuo Ming} and Yeh, {Ming Long}",

year = "2011",

doi = "10.1109/NEMS.2011.6017398",

language = "English",

isbn = "9781612847757",

series = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

pages = "483--486",

booktitle = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

note = "6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 ; Conference date: 20-02-2011 Through 23-02-2011",

}

Chen, WC, Hsieh, CH, Li, CH, Tseng, YC, Wang, KM & Yeh, ML 2011, The migration of cancer and normal cells in response to the surface topography and rigidity. 於 NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems., 6017398, NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 頁 483-486, 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011, Kaohsiung, Taiwan, 11-02-20. https://doi.org/10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity. / Chen, Wen Chi; Hsieh, Chin Ho; Li, Chia Hui 等.
NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 483-486 6017398 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems).

研究成果: Conference contribution

TY - GEN

T1 - The migration of cancer and normal cells in response to the surface topography and rigidity

AU - Chen, Wen Chi

AU - Hsieh, Chin Ho

AU - Li, Chia Hui

AU - Tseng, Yu Chieh

AU - Wang, Kuo Ming

AU - Yeh, Ming Long

PY - 2011

Y1 - 2011

N2 - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

AB - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

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DO - 10.1109/NEMS.2011.6017398

M3 - Conference contribution

AN - SCOPUS:80053301435

SN - 9781612847757

T3 - NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

SP - 483

EP - 486

BT - NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

T2 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011

Y2 - 20 February 2011 through 23 February 2011

ER -

Chen WC, Hsieh CH, Li CH, Tseng YC, Wang KM, Yeh ML. The migration of cancer and normal cells in response to the surface topography and rigidity. 於 NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 483-486. 6017398. (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). doi: 10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity

摘要

出版系列

Other

All Science Journal Classification (ASJC) codes

UN SDG

存取文件

其它文件與鏈接

指紋

引用此