The monocyte-macrophage-mast cell axis in dengue pathogenesis

Shu Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen Yu Chen, Yan Huang, Robert Anderson

研究成果: Review article

2 引文 (Scopus)

摘要

Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages and mast cells which are important regulators of vascular integrity and which undergo dramatic cellular responses after infection by dengue virus. The strategic locations of these three cell types, inside blood vessels (monocytes) or outside blood vessels (macrophages and mast cells) allow them to respond to dengue virus infection with the production of both intracellular and secretory factors which affect virus replication, vascular permeability and/or leukocyte extravasation. Moreover, the expression of Fc receptors on the surface of monocytes, macrophages and mast cells makes them important target cells for antibody-enhanced dengue virus infection which is a major risk factor for severe dengue disease, involving hemorrhage. Collectively, these features of monocytes, macrophages and mast cells contribute to both beneficial and harmful responses of importance to understanding and controlling dengue infection and disease.

原文English
文章編號77
期刊Journal of biomedical science
25
發行號1
DOIs
出版狀態Published - 2018 十一月 8

指紋

Dengue Virus
Dengue
Macrophages
Viruses
Mast Cells
Monocytes
Blood Vessels
Virus Diseases
Blood vessels
Severe Dengue
Fc Receptors
Capillary Permeability
Virus Replication
Infection
Leukocytes
Hemorrhage
Health
Antibodies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

引用此文

Wan, Shu Wen ; Wu-Hsieh, Betty A. ; Lin, Yee-Shin ; Chen, Wen Yu ; Huang, Yan ; Anderson, Robert. / The monocyte-macrophage-mast cell axis in dengue pathogenesis. 於: Journal of biomedical science. 2018 ; 卷 25, 編號 1.
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The monocyte-macrophage-mast cell axis in dengue pathogenesis. / Wan, Shu Wen; Wu-Hsieh, Betty A.; Lin, Yee-Shin; Chen, Wen Yu; Huang, Yan; Anderson, Robert.

於: Journal of biomedical science, 卷 25, 編號 1, 77, 08.11.2018.

研究成果: Review article

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AU - Wan, Shu Wen

AU - Wu-Hsieh, Betty A.

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AU - Huang, Yan

AU - Anderson, Robert

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AB - Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages and mast cells which are important regulators of vascular integrity and which undergo dramatic cellular responses after infection by dengue virus. The strategic locations of these three cell types, inside blood vessels (monocytes) or outside blood vessels (macrophages and mast cells) allow them to respond to dengue virus infection with the production of both intracellular and secretory factors which affect virus replication, vascular permeability and/or leukocyte extravasation. Moreover, the expression of Fc receptors on the surface of monocytes, macrophages and mast cells makes them important target cells for antibody-enhanced dengue virus infection which is a major risk factor for severe dengue disease, involving hemorrhage. Collectively, these features of monocytes, macrophages and mast cells contribute to both beneficial and harmful responses of importance to understanding and controlling dengue infection and disease.

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