The monocyte-macrophage-mast cell axis in dengue pathogenesis

Shu Wen Wan, Betty A. Wu-Hsieh, Yee Shin Lin, Wen Yu Chen, Yan Huang, Robert Anderson

研究成果: Review article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages and mast cells which are important regulators of vascular integrity and which undergo dramatic cellular responses after infection by dengue virus. The strategic locations of these three cell types, inside blood vessels (monocytes) or outside blood vessels (macrophages and mast cells) allow them to respond to dengue virus infection with the production of both intracellular and secretory factors which affect virus replication, vascular permeability and/or leukocyte extravasation. Moreover, the expression of Fc receptors on the surface of monocytes, macrophages and mast cells makes them important target cells for antibody-enhanced dengue virus infection which is a major risk factor for severe dengue disease, involving hemorrhage. Collectively, these features of monocytes, macrophages and mast cells contribute to both beneficial and harmful responses of importance to understanding and controlling dengue infection and disease.

原文English
文章編號77
期刊Journal of biomedical science
25
發行號1
DOIs
出版狀態Published - 2018 十一月 8

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

指紋 深入研究「The monocyte-macrophage-mast cell axis in dengue pathogenesis」主題。共同形成了獨特的指紋。

引用此