TY - JOUR
T1 - The non-canonical role of vascular endothelial growth factor-C axis in cancer progression
AU - Wang, Chu An
AU - Tsai, Shaw Jenq
N1 - Funding Information:
We apologize to those authors whose work has not been cited. We thank Dr Marcus J. Calkins for proofreading of this current manuscript. Chu-An Wang is funded by grant from Ministry of Sciences and Technology, Taiwan (MOST 103-2321-B-006-020-MY3). Shaw-Jenq Tsai is funded by grants from National Research Program for Biopharmaceuticals (NSC 101-2325-B-006-017), National Health Research Institute (NHRI-EX-102-10244BI), and Top University grant of National Cheng Kung University (D103-35A17).
Publisher Copyright:
© 2015 by the Society for Experimental Biology and Medicine
PY - 2015/6/12
Y1 - 2015/6/12
N2 - It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.
AB - It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.
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U2 - 10.1177/1535370215583802
DO - 10.1177/1535370215583802
M3 - Article
C2 - 25888649
AN - SCOPUS:84930810191
SN - 1535-3702
VL - 240
SP - 718
EP - 724
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 6
ER -