The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients

Gen Min Lin, Yi Hwei Li, Wei Hsian Yin, Yen Wen Wu, Pao Hsien Chu, Chih Cheng Wu, Chih Hsin Hsu, Ming Shien Wen, Wen Chol Voon, Chun Chieh Wang, San Jou Yeh, Wei Shiang Lin, Kuei Chuan Chan, Heng Chia Chang, Kuan Cheng Chang, Zhih Cherng Chen, Shyh Ming Chen, Pao Hsien Chu, Chih Hsin Hsu, Jin Long HuangJen yuan Kuo, Jiunn Lee Lin, Wei Shiang Lin, Guang Yuan Mar, Kou Gi Shyu, Shih Hsien Sung, Wei Kung Tseng, Wen Chol Voon, Ji Hung Wang, Ming Shien Wen, Ning I. Yang

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

A global heart failure (HF) registry suggested that the inverse association between body mass index (BMI) and all-cause mortality differed by race, particularly stronger in Japanese patients at 1-year follow-up. Whether this finding was consistent across all East Asian populations was unknown. In a multicenter prospective study in Taiwan, we enrolled 1,301 patients hospitalized for systolic HF from 2013 to 2014 and followed up the mortality after their discharge for a median of 1-year period. Cox proportional hazard regression analyses were used to assess the association of BMI with all-cause mortality. The results showed that BMI was inversely associated with all-cause mortality (hazard ratio and 95% CI per 5-kg/m2 increase: 0.75 [0.62 to 0.91]) after adjusting for demographics, traditional risk factors, HF severity, and medications at discharge. Subsequently, we sought previous studies regarding the BMI association with mortality for East Asian patients with HF from Medline, and a random-effect meta-analysis was performed by the inverse variance method. The meta-analysis including 7 previous eligible studies (3 for the Chinese and 4 for the Japanese cohorts) and the present one showed similar results that BMI was inversely associated with all-cause mortality (hazard ratio 0.65 [0.58 to 0.73], I2 = 37%). In conclusion, our study in Taiwan and a collaborative meta-analysis confirmed a strong inverse BMI-mortality association consistently among East Asian patients with HF.

原文English
頁(從 - 到)1011-1018
頁數8
期刊American Journal of Cardiology
118
發行號7
DOIs
出版狀態Published - 2016 十月 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

指紋 深入研究「The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients」主題。共同形成了獨特的指紋。

引用此