The Pathobiome in Animal and Plant Diseases

David Bass, Grant D. Stentiford, Han Ching Wang, Britt Koskella, Charles R. Tyler

研究成果: Review article同行評審

35 引文 斯高帕斯(Scopus)

摘要

A growing awareness of the diversity and ubiquity of microbes (eukaryotes, prokaryotes, and viruses) associated with larger ‘host’ organisms has led to the realisation that many diseases thought to be caused by one primary agent are the result of interactions between multiple taxa and the host. Even where a primary agent can be identified, its effect is often moderated by other symbionts. Therefore, the one pathogen–one disease paradigm is shifting towards the pathobiome concept, integrating the interaction of multiple symbionts, host, and environment in a new understanding of disease aetiology. Taxonomically, pathobiomes are variable across host species, ecology, tissue type, and time. Therefore, a more functionally driven understanding of pathobiotic systems is necessary, based on gene expression, metabolic interactions, and ecological processes.

原文English
頁(從 - 到)996-1008
頁數13
期刊Trends in Ecology and Evolution
34
發行號11
DOIs
出版狀態Published - 2019 十一月

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

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