The possible neuronal mechanism of acupuncture: Morphological evidence of the neuronal connection between groin A-shi point and uterus

Chun Yen Chen, Rey Shyong Chern, Ming Huei Liao, Yung Hsien Chang, Jung Yu C. Hsu, Chi Hsien Chien

研究成果: Article

5 引文 斯高帕斯(Scopus)

摘要

Somatovisceral reflex suggested that the somatic stimulation could affect visceral function like acupuncture which treats diseases by stimulating acupoints. The neuronal connection between somatic point and visceral organ was not clear. Uterine pain referred to the groin region has long been recognized clinically. Wesselmann, using neurogenic plasma extravasation method, showed that uterine pain was referred to the groin region through a neuronal mechanism (Wesselmann and Lai 1997). This connection could be considered through the somatovisceral reflex pathway. However, the relay center of this pathway is still not clearly identified. In the present study, bee venom was injected in the groin region to induce central Fos expression to map the sensory innervation of groin region. Pseudorabies virus (PrV), a transneuronal tracer, was injected in the uterus to identify the higher motor control of the uterus. Immunohistochemistry staining revealed the Fos expression and PrV-infected double-labeled neurons in the nucleus of solitary tract (NTS), the dorsal motor nucleus of vagus (DMX), and the paraventricular hypothalamic nucleus (PVN). These results suggest a somatoparasympathetic neuronal connection (groin-spinal dorsal horn-NTS/DMX-uterus) and a somatosympathetic neuronal connection (groin-spinal dorsal horn-NTS-PVN-uterus). These two neuronal connections could be the prerequisites to the neuronal basis of the somatovisceral reflex and also the neuronal mechanism of acupuncture.

原文English
文章編號429186
期刊Evidence-based Complementary and Alternative Medicine
2013
DOIs
出版狀態Published - 2013 四月 2

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

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