The potential role of epigenetic modulations in BPPV maneuver exercises

Kun Ling Tsai, Chia To Wang, Chia Hua Kuo, Yuan Yang Cheng, Hsin I. Ma, Ching Hsia Hung, Yi Ju Tsai, Chung Lan Kao

研究成果: Article

2 引文 (Scopus)

摘要

Benign paroxysmal positional vertigo (BPPV) is one of the most common complaints encountered in clinics and is strongly correlated with advanced age or, possibly, degeneration. Redistribution exercises are the most effective approaches to treat BPPV, and canalith repositioning procedure (CRP) cure most BPPV cases. However, the mechanisms through which the treatment modulates systemic molecules in BPPV patients remain largely unknown. In this study, we report that the miR-34a and Sirtuin 1 (SIRT1) genes correlated with the treatment effects of CRP in BPPV subjects. We found that miR-34a expression was largely inhibited and SIRT1 expression was significantly reversed after BPPV maneuver treatment. We also confirmed that the PPAR-γ, PGC-1 and FoxO gene expressions were decreased immediately after canalith repositioning procedure (CRP) for BPPV, and were largely increased after a complete cure of BPPV. Moreover, we observed that after a complete recovery of BPPV, the ROS concentrations, pro-inflammatory cytokine concentrations and p53 expression levels were attenuated. We conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status.

原文English
頁(從 - 到)35522-35534
頁數13
期刊Oncotarget
7
發行號24
DOIs
出版狀態Published - 2016 一月 1

指紋

Epigenomics
Exercise
Sirtuin 1
Benign Paroxysmal Positional Vertigo
Peroxisome Proliferator-Activated Receptors
Therapeutics
Oxidation-Reduction
Cytokines
Gene Expression

All Science Journal Classification (ASJC) codes

  • Oncology

引用此文

Tsai, K. L., Wang, C. T., Kuo, C. H., Cheng, Y. Y., Ma, H. I., Hung, C. H., ... Kao, C. L. (2016). The potential role of epigenetic modulations in BPPV maneuver exercises. Oncotarget, 7(24), 35522-35534. https://doi.org/10.18632/oncotarget.9446
Tsai, Kun Ling ; Wang, Chia To ; Kuo, Chia Hua ; Cheng, Yuan Yang ; Ma, Hsin I. ; Hung, Ching Hsia ; Tsai, Yi Ju ; Kao, Chung Lan. / The potential role of epigenetic modulations in BPPV maneuver exercises. 於: Oncotarget. 2016 ; 卷 7, 編號 24. 頁 35522-35534.
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The potential role of epigenetic modulations in BPPV maneuver exercises. / Tsai, Kun Ling; Wang, Chia To; Kuo, Chia Hua; Cheng, Yuan Yang; Ma, Hsin I.; Hung, Ching Hsia; Tsai, Yi Ju; Kao, Chung Lan.

於: Oncotarget, 卷 7, 編號 24, 01.01.2016, p. 35522-35534.

研究成果: Article

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