The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice

Dur Zong Hsu, Chang Hsin Wan, Hua Fen Hsu, Yung Ming Lin, Ming Yie Liu

研究成果: Article同行評審

31 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.

原文English
頁(從 - 到)2736-2741
頁數6
期刊Food and Chemical Toxicology
46
發行號8
DOIs
出版狀態Published - 2008 8月 1

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 毒理學

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