The proteome targets of intracellular targeting antimicrobial peptides

Pramod Shah, Felix Shih Hsiang Hsiao, Yu Hsuan Ho, Chien Sheng Chen

研究成果: Review article同行評審

34 引文 斯高帕斯(Scopus)

摘要

Antimicrobial peptides have been considered well-deserving candidates to fight the battle against microorganisms due to their broad-spectrum antimicrobial activities. Several studies have suggested that membrane disruption is the basic mechanism of AMPs that leads to killing or inhibiting microorganisms. Also, AMPs have been reported to interact with macromolecules inside the microbial cells such as nucleic acids (DNA/RNA), protein synthesis, essential enzymes, membrane septum formation and cell wall synthesis. Proteins are associated with many intracellular mechanisms of cells, thus protein targets may be specifically involved in mechanisms of action of AMPs. AMPs like pyrrhocoricin, drosocin, apidecin and Bac 7 are documented to have protein targets, DnaK and GroEL. Moreover, the intracellular targeting AMPs are reported to influence more than one protein targets inside the cell, suggesting for the multiple modes of actions. This complex mechanism of intracellular targeting AMPs makes them more difficult for the development of resistance. Herein, we have summarized the current status of AMPs in terms of their mode of actions, entry to cytoplasm and inhibition of macromolecules. To reveal the mechanism of action, we have focused on AMPs with intracellular protein targets. We have also included the use of high-throughput proteome microarray to determine the unidentified AMP protein targets in this review.

原文English
頁(從 - 到)1225-1237
頁數13
期刊Proteomics
16
發行號8
DOIs
出版狀態Published - 2016 四月 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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