The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)

Ramya Kumar, Jiun Yan Huang, Yen Siong Ng, Cong Yan Chen, Han Ching Wang

研究成果: Review article同行評審

14 引文 斯高帕斯(Scopus)

摘要

For more than three decades, infectious diseases have been one of the major causes of economic losses in the global shrimp industry. One of the deadliest of the shrimp pathogens is white spot syndrome virus (WSSV), which causes mass mortality in farmed shrimp. Various aspects of WSSV pathogenicity have been studied, but in this review, we will focus only on one of them, namely metabolic reprogramming. WSSV’s modulation of host metabolism affects glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis and lipid metabolism. Several signaling pathways are involved in this regulation, including JAK-STAT, PI3K-AKT-mTOR, MAPK and Ras-Raf-MEK, with the PI3K-Akt-mTOR pathway in particular playing a critical role in activating the WSSV-induced Warburg effect. Taken together, these changes benefit the virus by facilitating WSSV replication. In this review, we summarize current knowledge regarding the metabolism-related aspects of WSSV pathogenesis, and discuss the mechanisms by which this virus reprograms its host's metabolic pathways. A deeper understanding of these pathways, key metabolic enzymes and signaling mechanisms is potentially important for the development of effective anti-WSSV strategies.

原文English
頁(從 - 到)1150-1169
頁數20
期刊Reviews in Aquaculture
14
發行號3
DOIs
出版狀態Published - 2022 6月

All Science Journal Classification (ASJC) codes

  • 海洋科學
  • 生態學
  • 管理、監督、政策法律

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