The role of cholesterol in prostatic diseases

研究成果: Review article

4 引文 (Scopus)

摘要

Cholesterol is a neutral lipid that plays an essential role in the maintenance of the integrity of biologic membranes and serves as a precursor in the synthesis of many endocrine mediators. It is also synthesized in mammalian cells via the mevalonate pathway. Recent clinical and basic research evidence has demonstrated a possible linkage of cholesterol to two of the most common diseases of the human prostate: prostatic cancer and benign prostatic hyperplasia. Accumulation of cholesterol within the lipid raft component of the cellular plasma membrane may stimulate signaling pathways that promote prostate tumor growth and progression. In addition, cholesterol-lowering drugs, such as statins, have exhibited some promising results for these prostatic diseases. This new area of research may provide insight into the underlying cellular mechanisms leading to prostate hyperplasia, prostate cancer progression, and potentially novel targets for therapeutic interventions.

原文English
頁(從 - 到)97-102
頁數6
期刊Urological Science
22
發行號3
DOIs
出版狀態Published - 2011 一月 1

指紋

Prostatic Diseases
Cholesterol
Prostatic Neoplasms
Prostate
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mevalonic Acid
Prostatic Hyperplasia
Research
Hyperplasia
Maintenance
Cell Membrane
Membranes
Growth
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

引用此文

@article{3d3824c6bc78413ba61334a1a75e4981,
title = "The role of cholesterol in prostatic diseases",
abstract = "Cholesterol is a neutral lipid that plays an essential role in the maintenance of the integrity of biologic membranes and serves as a precursor in the synthesis of many endocrine mediators. It is also synthesized in mammalian cells via the mevalonate pathway. Recent clinical and basic research evidence has demonstrated a possible linkage of cholesterol to two of the most common diseases of the human prostate: prostatic cancer and benign prostatic hyperplasia. Accumulation of cholesterol within the lipid raft component of the cellular plasma membrane may stimulate signaling pathways that promote prostate tumor growth and progression. In addition, cholesterol-lowering drugs, such as statins, have exhibited some promising results for these prostatic diseases. This new area of research may provide insight into the underlying cellular mechanisms leading to prostate hyperplasia, prostate cancer progression, and potentially novel targets for therapeutic interventions.",
author = "Yat-Ching Tong",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.urols.2011.08.002",
language = "English",
volume = "22",
pages = "97--102",
journal = "Urological Science",
issn = "1879-5226",
publisher = "Elsevier",
number = "3",

}

The role of cholesterol in prostatic diseases. / Tong, Yat-Ching.

於: Urological Science, 卷 22, 編號 3, 01.01.2011, p. 97-102.

研究成果: Review article

TY - JOUR

T1 - The role of cholesterol in prostatic diseases

AU - Tong, Yat-Ching

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Cholesterol is a neutral lipid that plays an essential role in the maintenance of the integrity of biologic membranes and serves as a precursor in the synthesis of many endocrine mediators. It is also synthesized in mammalian cells via the mevalonate pathway. Recent clinical and basic research evidence has demonstrated a possible linkage of cholesterol to two of the most common diseases of the human prostate: prostatic cancer and benign prostatic hyperplasia. Accumulation of cholesterol within the lipid raft component of the cellular plasma membrane may stimulate signaling pathways that promote prostate tumor growth and progression. In addition, cholesterol-lowering drugs, such as statins, have exhibited some promising results for these prostatic diseases. This new area of research may provide insight into the underlying cellular mechanisms leading to prostate hyperplasia, prostate cancer progression, and potentially novel targets for therapeutic interventions.

AB - Cholesterol is a neutral lipid that plays an essential role in the maintenance of the integrity of biologic membranes and serves as a precursor in the synthesis of many endocrine mediators. It is also synthesized in mammalian cells via the mevalonate pathway. Recent clinical and basic research evidence has demonstrated a possible linkage of cholesterol to two of the most common diseases of the human prostate: prostatic cancer and benign prostatic hyperplasia. Accumulation of cholesterol within the lipid raft component of the cellular plasma membrane may stimulate signaling pathways that promote prostate tumor growth and progression. In addition, cholesterol-lowering drugs, such as statins, have exhibited some promising results for these prostatic diseases. This new area of research may provide insight into the underlying cellular mechanisms leading to prostate hyperplasia, prostate cancer progression, and potentially novel targets for therapeutic interventions.

UR - http://www.scopus.com/inward/record.url?scp=82455179438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455179438&partnerID=8YFLogxK

U2 - 10.1016/j.urols.2011.08.002

DO - 10.1016/j.urols.2011.08.002

M3 - Review article

AN - SCOPUS:82455179438

VL - 22

SP - 97

EP - 102

JO - Urological Science

JF - Urological Science

SN - 1879-5226

IS - 3

ER -