The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications

研究成果: Review article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.

原文English
頁(從 - 到)919-923
頁數5
期刊Journal of Leukocyte Biology
104
發行號5
DOIs
出版狀態Published - 2018 十一月

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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