The Role of the Amygdala in the Extinction of Conditioned Fear

Mark Barad, Po Wu Gean, Beat Lutz

研究成果: Review article同行評審

115 引文 斯高帕斯(Scopus)

摘要

The amygdala has long been known to play a central role in the acquisition and expression of fear. More recently, convergent evidence has implicated the amygdala in the extinction of fear as well. In rodents, some of this evidence comes from the infusion of drugs directly into the amygdala and, in particular, into the basolateral complex of the amygdala, during or after extinction learning. In vivo electrophysiology has identified cellular correlates of extinction learning and memory in the lateral nucleus of that structure. Human imaging experiments also indicate that amygdaloid activity correlates with extinction training. In addition, some studies have directly identified changes in molecular constituents of the basolateral amygdala. Together these experiments strongly indicate that the basolateral amygdala plays a crucial role in extinction learning. Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning.

原文English
頁(從 - 到)322-328
頁數7
期刊Biological Psychiatry
60
發行號4
DOIs
出版狀態Published - 2006 八月 15

All Science Journal Classification (ASJC) codes

  • 生物精神病學

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