The role of thrombomodulin in atherosclerosis: From bench to bedside

Yi Heng Li, Guey Yueh Shi, Hua Lin Wu

研究成果: Review article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Atherosclerosis remains a leading cause of morbidity and mortality worldwide. In addition to the deposition of cholesterol in the arterial wall, inflammation, cell proliferation and migration play important roles in the pathogenesis of atherosclerosis. Thrombomodulin (TM) is a cell surface-expressed glycoprotein which is predominantly synthesized by vascular endothelial cells and a critical cofactor for thrombin-mediated activation of protein C. Activated protein C is best known for its natural anticoagulant and anti-inflammatory properties. Recent evidence has revealed that TM also has protein C- and thrombin-independent physiological function. This review summarizes recent investigations of TM, giving an overview on the TM unique effects on cellular proliferation, adhesion and inflammation, all of which are important steps in atherosclerosis. The current evidence of TM in the pathogenesis of atherosclerosis will be reviewed, and the associations of TM gene polymorphisms with atherosclerosis are presented. Newly emerging data of the TM in mouse atherosclerosis model demonstrates that TM potentially may have therapeutic role in atherosclerosis.

原文English
頁(從 - 到)183-187
頁數5
期刊Cardiovascular and Hematological Agents in Medicinal Chemistry
4
發行號2
DOIs
出版狀態Published - 2006 四月

All Science Journal Classification (ASJC) codes

  • 血液學
  • 藥理
  • 心臟病學與心血管醫學

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