The selection of triple therapy for Helicobacter pylori eradication in chronic renal insufficiency

B. S. Sheu, J. J. Huang, H. B. Yang, A. H. Huang, J. J. Wu

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Aim: To establish a triple therapy regimen for Helicobacter pylori eradication in patients with chronic renal insufficiency. Methods: Eighty-eight patients with chronic renal insufficiency and H. pylori infection were evenly randomized into two groups receiving 1-week lansoprazole, 30 mg, clarithromycin, 500 mg, and either amoxicillin, 750 mg, or metronidazole, 500 mg, twice daily. The adverse events and compliance with triple therapy were reviewed at the week 1 visit. Patients provided stool samples at week 6 to assess the success of H. pylori eradication by H. pylori-specific stool antigen. The serum creatinine levels were monitored at enrolment, at weeks 1, 2 and 6 and on any unscheduled visit after triple therapy. Results: The success of H. pylori eradication was higher in the lansoprazole-clarithromycin-metronidazole group than in the lansoprazole-clarithromycin-amoxicillin group (intention-to-treat analysis: 84% vs, 66%, P < 0.05; per protocol analysis: 93% vs, 76%, P < 0.05). Complete drug compliance was also better in the lansoprazole-clarithromycin-metronidazole group than in the lansoprazole-clarithromycin-amoxicillin group (77% vs, 52%, P < 0.05). Patients in the lansoprazole-clarithromycin-metronidazole group had a lower risk of acute renal failure than those in the lansoprazole-clarithromycin-amoxicillin group (2% vs, 18%, P < 0.05; relative risk, 0.128, 95% confidence interval, 0.016-0.979). Conclusions: Triple therapy with metronidazole and clarithromycin, but not amoxicillin, can be used for H. pylori eradication in patients with chronic renal insufficiency, because it is more effective, well tolerated and less likely to cause deterioration of renal function.

原文English
頁(從 - 到)1283-1290
頁數8
期刊Alimentary Pharmacology and Therapeutics
17
發行號10
DOIs
出版狀態Published - 2003 5月 15

All Science Journal Classification (ASJC) codes

  • 肝病
  • 消化內科
  • 藥學(醫學)

指紋

深入研究「The selection of triple therapy for Helicobacter pylori eradication in chronic renal insufficiency」主題。共同形成了獨特的指紋。

引用此