The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines

Shih-Min Wang, Ih Hui Lu, Ya Lan Lin, Yee-Shin Lin, Jiunn Jong Wu, Woei-Jer Chuang, Ming T. Lin, Ching-Chuan Liu

研究成果: Article

20 引文 (Scopus)

摘要

Cytokines are intimately involved with the innate and adaptive immune response to bacterial infections. This study was designed to determine the expression of inflammatory cytokines in children by the severity of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. The study population consisted of 16 invasive, 20 noninvasive, and 24 pharyngeal colonization, and 21 healthy controls. All children underwent the laboratory tests and cytokine measurement. GAS isolates were analyzed for emm gene typing. Patients with invasive GAS diseases had significantly higher interferon (IFN)-γ, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-18 than those with noninvasive diseases, colonization, and healthy controls. There was no difference in tumor necrosis factor (TNF)-α, IL-12, and IL-2 levels among the groups. Elevated white blood cell counts and levels of C-reactive protein and C3 were detected only in patients with invasive diseases. emm1 and emm12 predominated in invasive disease and colonization. Children with invasive GAS infections exhibited significant up-regulation of plasma levels of IFN-γ, IL-1β, IL-6, IL-8, IL-10, and IL-18, and suppression of TNF-α and IL-12 during the acute phase of their illness. An exuberant cytokine response was associated with the severity of illness.

原文English
頁(從 - 到)165-169
頁數5
期刊Diagnostic Microbiology and Infectious Disease
61
發行號2
DOIs
出版狀態Published - 2008 六月 1

指紋

Streptococcus pyogenes
Streptococcus
Cytokines
Interleukin-18
Interleukin-12
Infection
Interleukin-8
Interleukin-1
Interleukin-10
Interferons
Interleukin-6
Tumor Necrosis Factor-alpha
Adaptive Immunity
Leukocyte Count
Bacterial Infections
Innate Immunity
C-Reactive Protein
Interleukin-2
Up-Regulation
Population

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy
  • Virology
  • Parasitology
  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology

引用此文

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abstract = "Cytokines are intimately involved with the innate and adaptive immune response to bacterial infections. This study was designed to determine the expression of inflammatory cytokines in children by the severity of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. The study population consisted of 16 invasive, 20 noninvasive, and 24 pharyngeal colonization, and 21 healthy controls. All children underwent the laboratory tests and cytokine measurement. GAS isolates were analyzed for emm gene typing. Patients with invasive GAS diseases had significantly higher interferon (IFN)-γ, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-18 than those with noninvasive diseases, colonization, and healthy controls. There was no difference in tumor necrosis factor (TNF)-α, IL-12, and IL-2 levels among the groups. Elevated white blood cell counts and levels of C-reactive protein and C3 were detected only in patients with invasive diseases. emm1 and emm12 predominated in invasive disease and colonization. Children with invasive GAS infections exhibited significant up-regulation of plasma levels of IFN-γ, IL-1β, IL-6, IL-8, IL-10, and IL-18, and suppression of TNF-α and IL-12 during the acute phase of their illness. An exuberant cytokine response was associated with the severity of illness.",
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AU - Lin, Ya Lan

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AU - Wu, Jiunn Jong

AU - Chuang, Woei-Jer

AU - Lin, Ming T.

AU - Liu, Ching-Chuan

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