The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines

Shih Min Wang, Ih Hui Lu, Ya Lan Lin, Yee Shin Lin, Jiunn Jong Wu, Woei Jer Chuang, Ming T. Lin, Ching Chuan Liu

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Cytokines are intimately involved with the innate and adaptive immune response to bacterial infections. This study was designed to determine the expression of inflammatory cytokines in children by the severity of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. The study population consisted of 16 invasive, 20 noninvasive, and 24 pharyngeal colonization, and 21 healthy controls. All children underwent the laboratory tests and cytokine measurement. GAS isolates were analyzed for emm gene typing. Patients with invasive GAS diseases had significantly higher interferon (IFN)-γ, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-18 than those with noninvasive diseases, colonization, and healthy controls. There was no difference in tumor necrosis factor (TNF)-α, IL-12, and IL-2 levels among the groups. Elevated white blood cell counts and levels of C-reactive protein and C3 were detected only in patients with invasive diseases. emm1 and emm12 predominated in invasive disease and colonization. Children with invasive GAS infections exhibited significant up-regulation of plasma levels of IFN-γ, IL-1β, IL-6, IL-8, IL-10, and IL-18, and suppression of TNF-α and IL-12 during the acute phase of their illness. An exuberant cytokine response was associated with the severity of illness.

原文English
頁(從 - 到)165-169
頁數5
期刊Diagnostic Microbiology and Infectious Disease
61
發行號2
DOIs
出版狀態Published - 2008 6月

All Science Journal Classification (ASJC) codes

  • 微生物學(醫學)
  • 傳染性疾病

指紋

深入研究「The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines」主題。共同形成了獨特的指紋。

引用此