The TFB4 subunit of yeast TFIIH is required for both nucleotide excision repair and RNA polymerase II transcription

William J. Feaver, Wenya Huang, Errol C. Friedberg

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

The N-degron strategy has been used to generate a yeast strain harboring a temperature-sensitive allele of TFB4 (tfb4(td)), the gene that encodes the 37-kDa subunit of the transcription/repair factor TFIIH. The tfb4(td) strain was sensitive to UV radiation and is defective in nucleotide excision repair in vitro. The mutant strain was also found to be an inositol auxotroph due at least in part to an inability to properly induce expression of the INO1 gene. These results indicate that like other subunits of TFIIH, Tfb4 is required for both RNA polymerase II transcription and DNA repair.

原文English
頁(從 - 到)29564-29567
頁數4
期刊Journal of Biological Chemistry
274
發行號41
DOIs
出版狀態Published - 1999 十月 8

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學
  • 細胞生物學

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