The three-body problem of therapy with induced pluripotent stem cells

Jakub Tolar; John A. McGrath

doi:10.1186/s13073-015-0141-7

The three-body problem of therapy with induced pluripotent stem cells

Jakub Tolar, John A. McGrath

皮膚學科

研究成果: Article › 同行評審

5 引文斯高帕斯（Scopus）

摘要

Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.

原文	English
文章編號	15
期刊	Genome Medicine
卷	7
發行號	1
DOIs	https://doi.org/10.1186/s13073-015-0141-7
出版狀態	Published - 2015 2月 20

All Science Journal Classification (ASJC) codes

分子醫學
分子生物學
遺傳學
遺傳學（臨床）

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10.1186/s13073-015-0141-7

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The three-body problem of therapy with induced pluripotent stem cells

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