The Use of alendronate is associated with a decreased incidence of type 2 diabetes mellitus - A population-based cohort study in Taiwan

Ding Cheng Chan, Rong Sen Yang, Chung Han Ho, Yau Sheng Tsai, Jhi Joung Wang, Kang Ting Tsai

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Purpose: Bone remodeling has been linked to glucose metabolism in animal studies, but the results of human trials were inconclusive. Bisphosphonates may play a role in glucose metabolism through their impacts on bone remodeling enzymes. In this study, we aimed to examine the influence of alendronate usage on the incidence of type 2 diabetes mellitus (DM) among osteoporotic patients. Methods: A retrospective cohort study was designed to include osteoporotic patients without DM from a population-based cohort containing 1,000,000 subjects. Patients treated with alendronate (exposed group, N=1,011) were compared with those who received no treatment (age and gender matched non-exposed group, N=3,033). Newly diagnosed DM was identified from medical records by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9CM) code. The incidence of DM in both groups was calculated for comparison. Results: The non-exposed group had a significantly higher incidence of DM (Odds ratio 1.21, 95% confidence interval 1.03-1.41) when compared with the exposed group. In subgroup analysis, the DM risk reduction in exposed group was only significant among those younger than 65 years and thosewithout hypertension or dyslipidemia. Patients who were prescribed alendronate more than or equal to 3 times had demonstrated a significant reduction in DM risk. Conclusions: Our study showed alendronate might yield a protective effect for incident DM. This effect became insignificant in patients with older age, dyslipidemia or hypertension. The underlying mechanism needs further exploration with prospective data for confirmation of the observed findings.

原文English
文章編號e0123279
期刊PloS one
10
發行號4
DOIs
出版狀態Published - 2015 四月 13

All Science Journal Classification (ASJC) codes

  • 多學科

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