The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis: A randomized clinical study

Kuo-An Lai, Wun Jer Shen, Chyun-Yu Yang, Chung Jung Shao, Jui Ting Hsu, Ruey Mo Lin

研究成果: Article同行評審

293 引文 斯高帕斯(Scopus)

摘要

Background: Osteonecrosis of the femoral head is the most common diagnosis leading to total hip arthroplasty in young adults. Joint-preserving treatment options have been mainly surgical, with inconsistent results. Alendronate (a bisphosphonate agent) has been shown to lower the prevalence of vertebral compression fractures and could potentially retard the collapse of an osteonecrotic femoral head. The purpose of this study was to test the effect of alendronate in preventing early collapse of the femoral head in patients with nontraumatic osteonecrosis. Methods: Forty patients with Steinberg stage-II or III nontraumatic osteonecrosis of the femoral head and a necrotic area of >30% (class C) were randomly divided into alendronate and control groups of twenty patients each. Patients in the alendronate group took 70 mg of alendronate orally per week for twenty-five weeks, while the patients in the control group did not receive this medication or a placebo. The patients were observed for a minimum of twenty-four months. Harris hip scores, plain radiographs, and magnetic resonance imaging scans were obtained. Results: During the study period, only two of twenty-nine femoral heads in the alendronate group collapsed, whereas nineteen of twenty-five femoral heads in the control group collapsed (p < 0.001). One hip in the alendronate group underwent total hip arthroplasty, whereas sixteen hips in the control group underwent total hip arthroplasty (p < 0.001). Conclusions: Alendronate appeared to prevent early collapse of the femoral head in the hips with Steinberg stage-II or IIIC nontraumatic osteonecrosis. A longer duration of follow-up is needed to confirm whether alendronate prevents or only retards collapse. Level of Evidence: Therapeutic Level I.

原文English
頁(從 - 到)2155-2159
頁數5
期刊Journal of Bone and Joint Surgery - Series A
87
發行號10
DOIs
出版狀態Published - 2005 十月 1

All Science Journal Classification (ASJC) codes

  • 手術
  • 骨科和運動醫學

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