The zona incerta modulates spontaneous spike-wave discharges in the rat

Fu Zen Shaw, Yi Fang Liao, Ruei Feng Chen, Yu Hsing Huang, Rick C.S. Lin

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7-to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior.

原文English
頁(從 - 到)2505-2516
頁數12
期刊Journal of Neurophysiology
109
發行號10
DOIs
出版狀態Published - 2013

All Science Journal Classification (ASJC) codes

  • 神經科學 (全部)
  • 生理學

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