Therapeutic Ultrasound Suppresses Neuropathic Pain and Upregulation of Substance P and Neurokinin-1 Receptor in Rats after Peripheral Nerve Injury

Yu Wen Chen, Jann Inn Tzeng, Po Ching Huang, Ching Hsia Hung, Dong Zi Shao, Jhi Joung Wang

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

We studied the mechanisms and impact of therapeutic ultrasound (TU) for pain caused by nerve injury. TU began on post-operative day 5 (POD5) and then continued daily for the next 22d. Sensitivity to thermal and mechanical stimuli and levels of neurokinin-1 receptor, substance P, tumor necrosis factor-α and interleukin-6 in the sciatic nerve were examined. On POD7, chronic constriction injury rats undergoing TU at an intensity of 1W/cm2, but not 0.25 or 0.5W/cm2, had increases in both the mechanical withdrawal threshold and the thermal withdrawal latency compared with the chronic constriction injury group. Moreover, chronic constriction injury rats exhibited upregulation of neurokinin-1 receptor, substance P, tumor necrosis factor-α and interleukin-6 in the sciatic nerve on PODs 14 and 28, whereas TU inhibited their increased expression. We suggest that the efficacy of TU is dependent on its ability to limit the upregulation of neurokinin-1 receptor, substance P, tumor necrosis factor-α and interleukin-6 around the injured sciatic nerve.

原文English
頁(從 - 到)143-150
頁數8
期刊Ultrasound in Medicine and Biology
41
發行號1
DOIs
出版狀態Published - 2015 1月 1

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 放射與超音波技術
  • 聲學與超音波

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