Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment

Yung Hsin Cheng, Tung Hu Tsai, Yong Yu Jhan, Allen Wen Hsiang Chiu, Kun Ling Tsai, Chian Shiu Chien, Shih Hwa Chiou, Catherine Jui Lin Liu

研究成果: Article同行評審

98 引文 斯高帕斯(Scopus)

摘要

Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment.

原文English
頁(從 - 到)390-399
頁數10
期刊Carbohydrate Polymers
144
DOIs
出版狀態Published - 2016 6月 25

All Science Journal Classification (ASJC) codes

  • 有機化學
  • 聚合物和塑料
  • 材料化學

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