TIAF1 participates in the transforming growth factor β1-mediated growth regulation

Smaira Khera, Nan Shan Chang

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)


TGF-β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF-β1-induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of cells. In contrast, like TGF-β1, TIAF1 supported transforming growth of L929 fibroblasts. TIAF1 increased the expression of p53, Cip1/p21, and Smad proteins; suppressed ERK phosphorylation; and altered TGF-β1-mediated Smad2/3 phosphorylation in U937 cells. Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-β-mediated growth regulation.

頁(從 - 到)11-21
期刊Annals of the New York Academy of Sciences
出版狀態Published - 2003 一月 1

All Science Journal Classification (ASJC) codes

  • 神經科學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 科學史與哲學


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