Time-to-positivity of blood culture: An independent prognostic factor of monomicrobial Pseudomonas aeruginosa bacteremia

Poh Chang Tang, Ching Chi Lee, Chia Wen Li, Ming Chi Li, Wen Chien Ko, Nan Yao Lee

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

Background/Purpose Pseudomonas aeruginosa bacteremia is an important cause of nosocomial infections with high morbidity and mortality. Time-to-positivity (TTP) of blood cultures is considered to be a predictor of the clinical outcome for bacteremia. The aim of the study is to investigate the relationship between TTP and clinical outcomes in patients with monomicrobial P. aeruginosa bacteremia. Methods From January 2013 to June 2014, a retrospective cohort study was conducted in a 1200-bed tertiary care hospital. The cases of monomicrobial P. aeruginosa bacteremia were studied. TTP and clinical parameters were determined and analyzed. Results In 139 cases of P. aeruginosa bacteremia, TTP ≤ 13 hours was associated with higher Pitt bacteremia scores (5.3 ± 4.2 vs. 2.3 ± 2.8, p < 0.001), severe sepsis (66.1% vs. 35.0%, p < 0.001), higher 30-day mortality rate (54.2% vs. 15.0%, p < 0.001), longer hospitalization in the survivors (25.6 ± 48.5 days vs. 16.3 ± 15.3 days, p = 0.16), and more admission to intensive care unit (27.2% vs. 16.3%, p = 0.14). Risk factors for 30-day mortality in the univariate analysis included corticosteroid exposure, primary bacteremia, concurrent pneumonia, a high Pitt bacteremia score, severe sepsis, and TTP ≤ 13 hours. In the multivariate analysis, primary bacteremia, a pulmonary origin of bacteremia, severe sepsis, and TTP ≤ 13 hours were independent risk factors for 30-day mortality. Conclusion In cases of monomicrobial P. aeruginosa bacteremia, a short TTP (≤ 13 hours) provides prognostic information, in addition to clinical parameters.

原文English
頁(從 - 到)486-493
頁數8
期刊Journal of Microbiology, Immunology and Infection
50
發行號4
DOIs
出版狀態Published - 2017 八月

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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