Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications

Dar Bin Shieh, I. Wen Chen, Tsai Yin Wei, Chuin Yi Shao, Hsin Ju Chang, Ching Hung Chung, Tung Yiu Wong, Ying Tai Jin

研究成果: Article同行評審

39 引文 斯高帕斯(Scopus)

摘要

Gelsolin has important cellular functions, including cell motility, proliferation and apoptosis. Altered gelsolin expression has been reported in several types of human malignancies, but has not been evaluated in oral carcinogenesis. In this study, all normal oral mucosa (n = 12) had high gelsolin expression, whereas only 7.7% of oral precancerous lesions (n = 26) had positive gelsolin expression. A significant increased positive staining was found in primary (n = 51; 37.3%) and metastatic (n = 26; 30.8%) oral squamous cell carcinoma lesions. Tumors with high gelsolin expression were associated with greater tumour size (P = 0.007), invasive growth (P = 0.02), and younger age (P = 0.006). High gelsolin expression conferred a poor clinical outcome in patients with metastatic disease (P = 0.005). In conclusion, a biphasic profile in gelsolin expression was observed during the progression of oral carcinogenesis. This may be due to a balance of its multiple cellular functions in tumour invasion and cell growth. The underlying mechanisms, however, remain to be elucidated.

原文English
頁(從 - 到)599-606
頁數8
期刊Oral Oncology
42
發行號6
DOIs
出版狀態Published - 2006 七月

All Science Journal Classification (ASJC) codes

  • 口腔外科
  • 腫瘤科
  • 癌症研究

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