Topical Tretinoin and Epithelial Wound Healing

Vincent C. Hung, Julia Yu Yun Lee, John A. Zitelli, Patricia A. Hebda

研究成果: Article同行評審

72 引文 斯高帕斯(Scopus)

摘要

The effects of topical tretinoin on epithelial wound healing were studied using a porcine model. Eight animals were treated with 0.05% tretinoin cream daily for ten days prior to partial-thickness skin wounding. Daily tretinoin treatment was continued after wounding on two of eight animals. Treatment with topical tretinoin before wounding accelerated epithelial wound healing in partial-thickness wounds. Continued tretinoin treatment on the wounds themselves retarded reepithelialization. Biopsy specimens of wounds with continued tretinoin treatment revealed persistent inflammation and fibroplasia in the dermis. The healing epithelium itself displayed areas of spongiosis and intracytoplasmic pale eosinophilic periodic acid-Schiff-positive, diastase-resistant globules. These globules did not stain with alcian blue. These epidermal alterations may be a direct effect of tretinoin or may be secondary to the underlying inflammation. While the dermal inflammation associated with continued tretinoin treatment appears to retard reepithelialization, epithelial cell alterations may also play a role.

原文English
頁(從 - 到)65-69
頁數5
期刊Archives of Dermatology
125
發行號1
DOIs
出版狀態Published - 1989 1月

All Science Journal Classification (ASJC) codes

  • 皮膚科

指紋

深入研究「Topical Tretinoin and Epithelial Wound Healing」主題。共同形成了獨特的指紋。

引用此