Topological Encoded Vector Beams for Monitoring Amyloid-Lipid Interactions in Microcavity

Chaoyang Gong, Zhen Qiao, Zhiyi Yuan, Shih Hsiu Huang, Wenjie Wang, Pin Chieh Wu, Yu Cheng Chen

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


Lasers are the pillars of modern photonics and sensing. Recent advances in microlasers have demonstrated its extraordinary lasing characteristics suitable for biosensing. However, most lasers utilized lasing spectrum as a detection signal, which can hardly detect or characterize nanoscale structural changes in microcavity. Here the concept of amplified structured light-molecule interactions is introduced to monitor tiny bio-structural changes in a microcavity. Biomimetic liquid crystal droplets with self-assembled lipid monolayers are sandwiched in a Fabry–Pérot cavity, where subtle protein-lipid membrane interactions trigger the topological transformation of output vector beams. By exploiting Amyloid β (Aβ)-lipid membrane interactions as a proof-of-concept, it is demonstrated that vector laser beams can be viewed as a topology of complex laser modes and polarization states. The concept of topological-encoded laser barcodes is therefore developed to reveal dynamic changes of laser modes and Aβ-lipid interactions with different Aβ assembly structures. The findings demonstrate that the topology of vector beams represents significant features of intracavity nano-structural dynamics resulted from structured light-molecule interactions.

期刊Advanced Science
出版狀態Published - 2021 六月 23

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 化學工程 (全部)
  • 材料科學(全部)
  • 生物化學、遺傳與分子生物學(雜項)
  • 工程 (全部)
  • 物理與天文學 (全部)


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