Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

Yakun Wan, Weiming Chen, Jie Xing, Jinyin Tan, Bing Li, Huiying Chen, Zhanxian Lin, Jung Hsien Chiang, Saleem Ramsey

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.

原文English
頁(從 - 到)2519-2525
頁數7
期刊FEBS Letters
585
發行號15
DOIs
出版狀態Published - 2011 八月 4

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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