Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

Yakun Wan; Weiming Chen; Jie Xing; Jinyin Tan; Bing Li; Huiying Chen; Zhanxian Lin; Jung Hsien Chiang; Saleem Ramsey

doi:10.1016/j.febslet.2011.06.036

Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

Yakun Wan, Weiming Chen, Jie Xing, Jinyin Tan, Bing Li, Huiying Chen, Zhanxian Lin, Jung Hsien Chiang, Saleem Ramsey

資訊工程學系

研究成果: Article › 同行評審

5 引文斯高帕斯（Scopus）

摘要

The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.

原文	English
頁（從 - 到）	2519-2525
頁數	7
期刊	FEBS Letters
卷	585
發行號	15
DOIs	https://doi.org/10.1016/j.febslet.2011.06.036
出版狀態	Published - 2011 8月 4

All Science Journal Classification (ASJC) codes

生物物理學
結構生物學
生物化學
分子生物學
遺傳學
細胞生物學

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10.1016/j.febslet.2011.06.036

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title = "Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing",

abstract = "The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.",

author = "Yakun Wan and Weiming Chen and Jie Xing and Jinyin Tan and Bing Li and Huiying Chen and Zhanxian Lin and Chiang, {Jung Hsien} and Saleem Ramsey",

note = "Funding Information: We thank members of the Yakun Wan{\textquoteright}s laboratory for helpful comments and discussion during the course of this project. This work was supported by grants The National Natural Science Foundation of China ( 31071146 ), and Excellent Young Teachers Program of Southeast University ( 3231001201 ) to Yakun Wan. Jie Xing is supported in part by National Natural Science Foundation of China (No. 30901829 ) and Shandong Natural Science Foundation of China (No. BS2009SW013 ). ",

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AU - Wan, Yakun

AU - Chen, Weiming

AU - Xing, Jie

AU - Tan, Jinyin

AU - Li, Bing

AU - Chen, Huiying

AU - Lin, Zhanxian

AU - Chiang, Jung Hsien

AU - Ramsey, Saleem

N1 - Funding Information: We thank members of the Yakun Wan’s laboratory for helpful comments and discussion during the course of this project. This work was supported by grants The National Natural Science Foundation of China ( 31071146 ), and Excellent Young Teachers Program of Southeast University ( 3231001201 ) to Yakun Wan. Jie Xing is supported in part by National Natural Science Foundation of China (No. 30901829 ) and Shandong Natural Science Foundation of China (No. BS2009SW013 ).

PY - 2011/8/4

Y1 - 2011/8/4

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AB - The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.

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Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

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