Transformation kinetics and pathways of tetracycline antibiotics with manganese oxide

Wan Ru Chen, Ching Hua Huang

研究成果: Article同行評審

144 引文 斯高帕斯(Scopus)


Tetracycline antibiotics including tetracycline (TTC), oxytetracycline (OTC) and chlorotetracycline (CTC) undergo rapid transformation to yield various products in the presence of MnO2 at mild conditions (pH 4-9 and 22 °C). Reaction rates follow the trend of CTC > TTC > OTC, and are affected by pH and complexation of TCs with Mg2+ or Ca2+. Experimental results of TTC indicate that MnO2 promotes isomerization at the C ring to form iso-TTC and oxidizes the phenolic-diketone and tricarbonylamide groups, leading to insertion of up to 2 O most likely at the C9 and C2 positions. In contrast, reactions of OTC with MnO2 generate little iso-OTC, but occur mainly at the A ring's dimethylamine group to yield N-demethylated products. CTC yields the most complicated products upon reactions with MnO2, encompassing transformation patterns observed with both TTC and OTC. The identified product structures suggest lower antibacterial activity than that of the parent tetracyclines.

頁(從 - 到)1092-1100
期刊Environmental Pollution
出版狀態Published - 2011 5月

All Science Journal Classification (ASJC) codes

  • 毒理學
  • 污染
  • 健康、毒理學和誘變


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