Tuning the Distance of Rattle-Shaped IONP@Shell-in-Shell Nanoparticles for Magnetically-Targeted Photothermal Therapy in the Second Near-Infrared Window

Ming Fong Tsai, Chin Hsu, Chen Sheng Yeh, Yu Jen Hsiao, Chia Hao Su, Li Fang Wang

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

Construction of multifunctional nanoparticles (NPs) with near-infrared (NIR) plasmonic responses is considered a versatile and multifaceted platform for several biomedical applications. Herein, a double layer of Au/Ag alloy on the surface of truncated octahedral iron oxide NPs (IONPs) was prepared and the distance between the layers was controlled to exhibit broad and strong NIR absorption. The rattle-shaped IONP@shell-in-shell nanostructure showed light-response to the NIR biological window from 650 to 1300 nm for photothermal therapy (PTT) and magnetic guidance for hyperthermia and magnetic resonance imaging (MRI) diagnosis. Exposing the aqueous solution of IONP@shell-in-shell to a 1064 nm diode laser, its heat conversion efficiency was ∼28.3%. The in vitro cell viability at a gold concentration of 100 ppm was ∼85%, and decreased to ∼16% when the cells were treated with the NIR irradiation and magnetic attraction. T2-weighted MRI images showed a clear accumulation of IONP@shell-in-shell at the tumor site with magnetic attraction. In vivo luminescence tumor images explained that the IONP@shell-in-shell could reduce the U87MG-luc2 cancer cell proliferation in mice with the NIR irradiation and magnetic attraction. These results indicate the IONP@shell-in-shell as a promising nanomedicine for PTT, magnetic targeting, and magnetic resonance imaging (MRI).

原文English
頁(從 - 到)1508-1519
頁數12
期刊ACS Applied Materials and Interfaces
10
發行號2
DOIs
出版狀態Published - 2018 一月 17

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)

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