摘要
A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 30467-30474 |
| 頁數 | 8 |
| 期刊 | ACS Applied Materials and Interfaces |
| 卷 | 8 |
| 發行號 | 44 |
| DOIs | |
| 出版狀態 | Published - 2016 十一月 9 |
指紋
All Science Journal Classification (ASJC) codes
- Materials Science(all)
引用此文
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Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots. / Kuo, Wen Shuo; Chang, Chia-Yuan; Chen, Hua Han; Hsu, Chih-Li; Wang, Jiu-Yao; Kao, Hui Fang; Chou, Lawrence Chao Shan; Chen, Yi-Chun; Chen, Shean Jen; Chang, Wen-Tsan; Tseng, Shih Wen; Wu, Ping-Ching; Pu, Ying Chih.
於: ACS Applied Materials and Interfaces, 卷 8, 編號 44, 09.11.2016, p. 30467-30474.研究成果: Article
TY - JOUR
T1 - Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots
AU - Kuo, Wen Shuo
AU - Chang, Chia-Yuan
AU - Chen, Hua Han
AU - Hsu, Chih-Li
AU - Wang, Jiu-Yao
AU - Kao, Hui Fang
AU - Chou, Lawrence Chao Shan
AU - Chen, Yi-Chun
AU - Chen, Shean Jen
AU - Chang, Wen-Tsan
AU - Tseng, Shih Wen
AU - Wu, Ping-Ching
AU - Pu, Ying Chih
PY - 2016/11/9
Y1 - 2016/11/9
N2 - A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.
AB - A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.
UR - http://www.scopus.com/inward/record.url?scp=84994524989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994524989&partnerID=8YFLogxK
U2 - 10.1021/acsami.6b12014
DO - 10.1021/acsami.6b12014
M3 - Article
C2 - 27753472
AN - SCOPUS:84994524989
VL - 8
SP - 30467
EP - 30474
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 44
ER -