Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Wen Shuo Kuo, Chia Yuan Chang, Hua Han Chen, Chih Li Lilian Hsu, Jiu Yao Wang, Hui Fang Kao, Lawrence Chao Shan Chou, Yi Chun Chen, Shean Jen Chen, Wen Tsan Chang, Shih Wen Tseng, Ping Ching Wu, Ying Chih Pu

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

原文English
頁(從 - 到)30467-30474
頁數8
期刊ACS Applied Materials and Interfaces
8
發行號44
DOIs
出版狀態Published - 2016 十一月 9

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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