Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Wen Shuo Kuo; Chia Yuan Chang; Hua Han Chen; Chih Li Lilian Hsu; Jiu Yao Wang; Hui Fang Kao; Lawrence Chao Shan Chou; Yi Chun Chen; Shean Jen Chen; Wen Tsan Chang; Shih Wen Tseng; Ping Ching Wu; Ying Chih Pu

doi:10.1021/acsami.6b12014

Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Wen Shuo Kuo, Chia Yuan Chang, Hua Han Chen, Chih Li Lilian Hsu, Jiu Yao Wang, Hui Fang Kao, Lawrence Chao Shan Chou, Yi Chun Chen, Shean Jen Chen, Wen Tsan Chang, Shih Wen Tseng, Ping Ching Wu, Ying Chih Pu

研究成果: Article › 同行評審

64 引文斯高帕斯（Scopus）

摘要

A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

原文	English
頁（從 - 到）	30467-30474
頁數	8
期刊	ACS Applied Materials and Interfaces
卷	8
發行號	44
DOIs	https://doi.org/10.1021/acsami.6b12014
出版狀態	Published - 2016 11月 9

All Science Journal Classification (ASJC) codes

材料科學(全部)

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10.1021/acsami.6b12014

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Kuo, W. S., Chang, C. Y., Chen, H. H., Hsu, C. L. L., Wang, J. Y., Kao, H. F., Chou, L. C. S., Chen, Y. C., Chen, S. J., Chang, W. T., Tseng, S. W., Wu, P. C., & Pu, Y. C. (2016). Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots. ACS Applied Materials and Interfaces, 8(44), 30467-30474. https://doi.org/10.1021/acsami.6b12014

@article{30e4390ef9154b45b0e19302bb2e4d36,

title = "Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots",

abstract = "A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.",

author = "Kuo, {Wen Shuo} and Chang, {Chia Yuan} and Chen, {Hua Han} and Hsu, {Chih Li Lilian} and Wang, {Jiu Yao} and Kao, {Hui Fang} and Chou, {Lawrence Chao Shan} and Chen, {Yi Chun} and Chen, {Shean Jen} and Chang, {Wen Tsan} and Tseng, {Shih Wen} and Wu, {Ping Ching} and Pu, {Ying Chih}",

note = "Funding Information: This research was supported by the Ministry of Science and Technology, Taiwan (MOST-103-2113-M-006-010-MY2; MOST-104-2321-B-006-008-; MOST-104-2314-B-006-076-MY3; MOST-104-2113-M-024-002-MY2), the Aim for the Top University Project and the National Science Council of Taiwan (NSC-105-2221-E-006?088), and Spark Taiwan- ANCHOR UNIVERSITY (MOST 105-2321-B-006-028). Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = nov,

day = "9",

doi = "10.1021/acsami.6b12014",

language = "English",

volume = "8",

pages = "30467--30474",

journal = "ACS applied materials & interfaces",

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publisher = "American Chemical Society",

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T1 - Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

AU - Kuo, Wen Shuo

AU - Chang, Chia Yuan

AU - Chen, Hua Han

AU - Hsu, Chih Li Lilian

AU - Wang, Jiu Yao

AU - Kao, Hui Fang

AU - Chou, Lawrence Chao Shan

AU - Chen, Yi Chun

AU - Chen, Shean Jen

AU - Chang, Wen Tsan

AU - Tseng, Shih Wen

AU - Wu, Ping Ching

AU - Pu, Ying Chih

N1 - Funding Information: This research was supported by the Ministry of Science and Technology, Taiwan (MOST-103-2113-M-006-010-MY2; MOST-104-2321-B-006-008-; MOST-104-2314-B-006-076-MY3; MOST-104-2113-M-024-002-MY2), the Aim for the Top University Project and the National Science Council of Taiwan (NSC-105-2221-E-006?088), and Spark Taiwan- ANCHOR UNIVERSITY (MOST 105-2321-B-006-028). Publisher Copyright: © 2016 American Chemical Society.

PY - 2016/11/9

Y1 - 2016/11/9

N2 - A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

AB - A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

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ER -

Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

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