Typhoid fever and typhoid hepatitis in Taiwan

J. L. Wang, J. H. Kao, S. P. Tseng, L. J. Teng, S. W. Ho, P. R. Hsueh

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

The annual incidence of typhoid fever in Taiwan was 2·1-3·6 cases per 1 000 000 population from 1995 to 2002. More than 80% of 45 patients with typhoid fever treated at National Taiwan University Hospital from 1996 to 2002 had elevated serum aminotransferase levels at presentation. Ten of these patients were treated during an outbreak in Taipei County in 2002, and seven of them who did not have pre-existing liver disease developed hepatitis, which was unrelated to other aetiologies. All Salmonella typhi isolates were susceptible to extended- spectrum cephalosporins and fluoroquinolones. Multidrug resistance (intermediate resistance to ampicillin, trimethoprim-sulphamethoxazole, and chloramphenicol) was found in one (2·5%) of the 40 isolates studied. Pulsed-field gel electrophoresis analysis demonstrated a high genetic diversity among S. typhi isolates and identified a novel clone associated with the 2002 outbreak. Physicians should be alert to the possibility of typhoid fever when patients, without other gastrointestinal symptoms, present with sustained fever and hepatitis.

原文English
頁(從 - 到)1073-1079
頁數7
期刊Epidemiology and Infection
133
發行號6
DOIs
出版狀態Published - 2005 十二月

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

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