TY - JOUR
T1 - Ultrasonic technologies in imaging and drug delivery
AU - Ho, Yi Ju
AU - Huang, Chih Chung
AU - Fan, Ching Hsiang
AU - Liu, Hao Li
AU - Yeh, Chih Kuang
N1 - Funding Information:
The authors gratefully acknowledge the support of the Ministry of Science and Technology, Taiwan under Grant No. MOST 108-2221-E-007-040-MY3, 108-2221-E-007-041-MY3, 108-2638-M-002-001-MY2, 107-2628-E-006-004-MY3, 107-2221-E-006-024-MY3, 109-2636-E-006-024-, 110-2321-B-002-010-, 108-2221-E-002-176-MY3, and 108-2221-E-002-175-MY3; National Tsing Hua University under Grant No. 110Q2510E1. The authors also thank to support from Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at NCKU.
Funding Information:
This work was supported by the Ministry of Science and Technology, Taiwan (Grant No. MOST 108-2221-E-007-040-MY3, 108-2221-E-007-041-MY3, 108-2638-M-002-001-MY2, 107-2628-E-006-004-MY3, 107-2221-E-006-024-MY3, 109-2636-E-006-024-, 110-2321-B-002-010-, 108-2221-E-002-176-MY3, and 108-2221-E-002-175-MY3), National Tsing Hua University (Grant No. 110Q2510E1), and Headquarters of University Advancement at NCKU.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2021/9
Y1 - 2021/9
N2 - Ultrasonic technologies show great promise for diagnostic imaging and drug delivery in theranostic applications. The development of functional and molecular ultrasound imaging is based on the technical breakthrough of high frame–rate ultrasound. The evolution of shear wave elastography, high-frequency ultrasound imaging, ultrasound contrast imaging, and super-resolution blood flow imaging are described in this review. Recently, the therapeutic potential of the interaction of ultrasound with microbubble cavitation or droplet vaporization has become recognized. Microbubbles and phase-change droplets not only provide effective contrast media, but also show great therapeutic potential. Interaction with ultrasound induces unique and distinguishable biophysical features in microbubbles and droplets that promote drug loading and delivery. In particular, this approach demonstrates potential for central nervous system applications. Here, we systemically review the technological developments of theranostic ultrasound including novel ultrasound imaging techniques, the synergetic use of ultrasound with microbubbles and droplets, and microbubble/droplet drug-loading strategies for anticancer applications and disease modulation. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theranostic tool.
AB - Ultrasonic technologies show great promise for diagnostic imaging and drug delivery in theranostic applications. The development of functional and molecular ultrasound imaging is based on the technical breakthrough of high frame–rate ultrasound. The evolution of shear wave elastography, high-frequency ultrasound imaging, ultrasound contrast imaging, and super-resolution blood flow imaging are described in this review. Recently, the therapeutic potential of the interaction of ultrasound with microbubble cavitation or droplet vaporization has become recognized. Microbubbles and phase-change droplets not only provide effective contrast media, but also show great therapeutic potential. Interaction with ultrasound induces unique and distinguishable biophysical features in microbubbles and droplets that promote drug loading and delivery. In particular, this approach demonstrates potential for central nervous system applications. Here, we systemically review the technological developments of theranostic ultrasound including novel ultrasound imaging techniques, the synergetic use of ultrasound with microbubbles and droplets, and microbubble/droplet drug-loading strategies for anticancer applications and disease modulation. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theranostic tool.
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U2 - 10.1007/s00018-021-03904-9
DO - 10.1007/s00018-021-03904-9
M3 - Review article
C2 - 34297166
AN - SCOPUS:85111077881
SN - 1420-682X
VL - 78
SP - 6119
EP - 6141
JO - Experientia
JF - Experientia
IS - 17-18
ER -