TY - JOUR
T1 - Ultrasound-activated nanomaterials for sonodynamic cancer theranostics
AU - Wu, Nan
AU - Fan, Ching Hsiang
AU - Yeh, Chih Kuang
N1 - Funding Information:
The authors gratefully acknowledge the support of the Ministry of Science and Technology, Taiwan, under grant numbers MOST 108-2221-E-007-041-MY3, 108-2221-E-007-040- MY3, 108-2638-M-002-001-MY2, 110-2221-E-007-019-MY3, and 110-2636-E-006-014, and of National Tsing Hua University, under grant number 110Q2510E1.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/6
Y1 - 2022/6
N2 - Despite intensive efforts to develop diagnostic and therapeutic tools, the successful treatment of cancer is still hampered by the obscure boundary between cancerous cells and normal cells, recurrence of the cancer, and the development of drug resistance during chemotherapy. In recent years, sonodynamic therapy (SDT), employing therapeutic ultrasound with sonosensitizers, has attracted attention as a potentially promising approach for cancer therapy. This review describes the current understanding of the mechanisms and the preclinical and clinical efficacy of SDT-based applications in tumors, providing an insight into the therapeutic potential offered by SDT. The limitations and future directions of this emerging treatment are also discussed.
AB - Despite intensive efforts to develop diagnostic and therapeutic tools, the successful treatment of cancer is still hampered by the obscure boundary between cancerous cells and normal cells, recurrence of the cancer, and the development of drug resistance during chemotherapy. In recent years, sonodynamic therapy (SDT), employing therapeutic ultrasound with sonosensitizers, has attracted attention as a potentially promising approach for cancer therapy. This review describes the current understanding of the mechanisms and the preclinical and clinical efficacy of SDT-based applications in tumors, providing an insight into the therapeutic potential offered by SDT. The limitations and future directions of this emerging treatment are also discussed.
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U2 - 10.1016/j.drudis.2022.02.025
DO - 10.1016/j.drudis.2022.02.025
M3 - Review article
C2 - 35247594
AN - SCOPUS:85126560261
SN - 1359-6446
VL - 27
SP - 1590
EP - 1603
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 6
ER -