Ultrasound-guided system for light focusing using microbubbles generated from polytetrafluoroethylene nanoparticles

Zong Han Hsieh, Ching Hsiang Fan, Meng Lin Li, Chih Kuang Yeh

研究成果: Article同行評審

摘要

Intrinsic lipid and protein components in biological tissues hamper the translation of light-related techniques to in vivo applications and highlight the need for strategies to improve photon trafficking. To meet this demand, we propose a method for the production of transient micro-sized bubbles to improve the local light intensity in the scattering medium by combining ultrasound and super hydrophobic polytetrafluoroethylene nanoparticles (PTFE NPs) with a mean size of 350 nm. The underlying idea was to convert the initial Rayleigh scattering effect into a Mie scattering effect to reduce loss during light propagation. The Monte Carlo simulation confirmed our hypothesis that only a specific size of microbubbles would increase light propagation. By fine-tuning the acoustic parameters (1.5 MPa, 100 cycles, and 10 Hz of pulse repetition frequency) and PTFE NPs' concentration (0.05 mg/ml), shell-less microbubbles were transiently and locally generated, resulting in a reduction in the scattering coefficient of the medium and improving the delivered light fluence by 6.2%. The experimental results further confirmed that only microbubbles of the proper size could repeatedly increase the light propagation. This method may be suitable for in vivo deep-tissue optical applications such as the delivery of PTFE NPs to deep tumor regions to increase the efficiency of photothermal therapy.

原文English
文章編號053701
期刊Applied Physics Letters
120
發行號5
DOIs
出版狀態Published - 2022 1月 31

All Science Journal Classification (ASJC) codes

  • 物理與天文學(雜項)

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