Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

Wei Peng Li, Chia Hao Su, Yi Ching Chang, Yu Jiung Lin, Chen Sheng Yeh

研究成果: Article同行評審

206 引文 斯高帕斯(Scopus)

摘要

Ultrasound techniques have been extensively employed for diagnostic purposes. Because of its features of low cost, easy access, and noninvasive real-time imaging, toward clinical practice it is highly anticipated to simply use diagnostic ultrasound to concurrently perform imaging and therapy. We report a H2O2-filled polymersome to display echogenic reflectivity and reactive oxygen species-mediated cancer therapy simply triggered by the microultrasound diagnostic system accompanied by MR imaging. Instead of filling common perfluorocarbons, the encapsulation of H2O2 in H2O2/Fe3O4-PLGA polymersome provides O2 as the echogenic source and OH as the therapeutic element. On exposure to ultrasound, the polymersome can be easily disrupted to yield OH through the Fenton reaction by reaction of H2O2 and Fe3O4. We showed that malignant tumors can be completely removed in a nonthermal process.

原文English
頁(從 - 到)2017-2027
頁數11
期刊ACS nano
10
發行號2
DOIs
出版狀態Published - 2016 二月 23

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)
  • 工程 (全部)
  • 物理與天文學 (全部)

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